- 专利标题： Efficient mucosal vaccination mediated by the neonatal Fc receptor
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申请号： US14961938申请日： 2015-12-08
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公开(公告)号： US10188724B2公开(公告)日： 2019-01-29
- 发明人: Xiaoping Zhu , Lilin Ye , Li Lu
- 申请人： University of Maryland, College Park
- 申请人地址： US MD College Park
- 专利权人： University of Maryland, College Park
- 当前专利权人： University of Maryland, College Park
- 当前专利权人地址： US MD College Park
- 代理机构： Hodgson Russ LLP
- 主分类号： A61K39/245
- IPC分类号： A61K39/245 ; C07K14/005 ; C07K14/315 ; C07K14/35 ; C07K14/47 ; A61K39/21 ; A61K39/12 ; C12N7/00 ; A61K39/00
摘要：
The present invention relates to methods and compositions for enhancing delivery of vaccine antigens to the mucosal epithelium, the composition comprising an antigen from an infectious agent fused with an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn). The composition is effective in eliciting a protective long-term memory T cell immune response against infection at a distant mucosal site.
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