There is disclosed a single-wire Interface bus transceiver system comprising: an I2C master, a master transceiver, a signal wire, a slave transceiver and an I2C slave, wherein the master transceiver is adapted to encode master data SDA and master clock SCL received from I2C master using Manchester code, generate master single wire signal and transfer it to the slave transceiver through the signal wire, the master transceiver is also adapted to decode Manchester-encoded slave signal received from the signal wire and transfer the decoded slave data to I2C master; the slave transceiver is adapted to encode slave data received from I2C slave using Manchester code, generate slave single wire signal and transfer it to the master transceiver through the signal wire, the slave transceiver is also adapted to decode Manchester-encoded master signal received from the signal wire, generate the recovered master clock and transfer the decoded master data and recovered master clock to I2C slave.