- 专利标题： Suspension containing nano-cocrystal and manufacturing method
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申请号： US15554688申请日： 2016-03-01
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公开(公告)号： US10226426B2公开(公告)日： 2019-03-12
- 发明人: Masatoshi Karashima , Katsuhiko Yamamoto , Takashi Kojima , Yukihiro Ikeda
- 申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 申请人地址： JP Osaka
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Casimir Jones, S.C.
- 代理商 Anne M. Reynolds
- 优先权： JP2015-040647 20150302
- 国际申请： PCT/JP2016/056236 WO 20160301
- 国际公布： WO2016/140219 WO 20160909
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K47/16 ; A61K47/18 ; A61K47/20 ; A61K47/22 ; A61K47/32 ; A61K47/34 ; A61K9/10 ; A61K47/38 ; A61K31/341 ; A61K31/405 ; A61K31/55 ; A61K31/522 ; A61K9/16
摘要：
The present invention provides a method of producing a suspension containing a nano-cocrystal having an average particle size of not more than 300 nm, a polymer having a number average molecular weight of not less than 3,000, a surfactant having a number average molecular weight of less than 3,000 and water, which method including wet grinding a cocrystal, which is constituted of an organic compound and a cocrystal former and is not dissociated by wet grinding, in water containing the polymer and the surfactant.