公开(公告)号：US10226426B2

公开(公告)日：2019-03-12

申请号：US15554688

申请日：2016-03-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masatoshi Karashima ,  Katsuhiko Yamamoto ,  Takashi Kojima ,  Yukihiro Ikeda

IPC: A61K9/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K9/10 ,  A61K47/38 ,  A61K31/341 ,  A61K31/405 ,  A61K31/55 ,  A61K31/522 ,  A61K9/16

Abstract: The present invention provides a method of producing a suspension containing a nano-cocrystal having an average particle size of not more than 300 nm, a polymer having a number average molecular weight of not less than 3,000, a surfactant having a number average molecular weight of less than 3,000 and water, which method including wet grinding a cocrystal, which is constituted of an organic compound and a cocrystal former and is not dissociated by wet grinding, in water containing the polymer and the surfactant.