Invention Grant
- Patent Title: Suspension containing nano-cocrystal and manufacturing method
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Application No.: US15554688Application Date: 2016-03-01
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Publication No.: US10226426B2Publication Date: 2019-03-12
- Inventor: Masatoshi Karashima , Katsuhiko Yamamoto , Takashi Kojima , Yukihiro Ikeda
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Casimir Jones, S.C.
- Agent Anne M. Reynolds
- Priority: JP2015-040647 20150302
- International Application: PCT/JP2016/056236 WO 20160301
- International Announcement: WO2016/140219 WO 20160909
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K47/16 ; A61K47/18 ; A61K47/20 ; A61K47/22 ; A61K47/32 ; A61K47/34 ; A61K9/10 ; A61K47/38 ; A61K31/341 ; A61K31/405 ; A61K31/55 ; A61K31/522 ; A61K9/16

Abstract:
The present invention provides a method of producing a suspension containing a nano-cocrystal having an average particle size of not more than 300 nm, a polymer having a number average molecular weight of not less than 3,000, a surfactant having a number average molecular weight of less than 3,000 and water, which method including wet grinding a cocrystal, which is constituted of an organic compound and a cocrystal former and is not dissociated by wet grinding, in water containing the polymer and the surfactant.
Public/Granted literature
- US20180036244A1 SUSPENSION OR COMPOSITION CONTAINING NANO-COCRYSTAL AND MANUFACTURING METHOD THEREFOR Public/Granted day:2018-02-08
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