A method includes a step of reacting a hydrocarbon-containing gas with an oxygen-containing gas to form a first product blend in a reactor. The first product blend includes a blend of partially oxygenated compounds. The blend of partially oxygenated compounds is provided to one or more reactive distillation stations; and The blend of partially oxygenated compounds is converted to a second product blend at one or more reactive distillation stations. Characteristically, the second product blend includes a mixture comprising a at least two of components selected from acetals, ethers, alcohols, esters, and alkenes.