Invention Grant
- Patent Title: Glutathione-detecting fluorescent probe
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Application No.: US15116661Application Date: 2015-02-24
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Publication No.: US10261090B2Publication Date: 2019-04-16
- Inventor: Yasuteru Urano , Mako Kamiya , Keitaro Umezawa , Masafumi Yoshida
- Applicant: THE UNIVERSITY OF TOKYO
- Applicant Address: JP Tokyo
- Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee Address: JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2014-037640 20140228
- International Application: PCT/JP2015/055276 WO 20150224
- International Announcement: WO2015/129705 WO 20150903
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C09B11/08 ; C09B11/24 ; C09B11/28 ; C09B19/00 ; C09K11/07 ; G01N21/64 ; C07F7/08 ; G01N33/58 ; C09K11/06

Abstract:
[Problem] To provide the following: a novel fluorescent probe for detecting a compound, such as glutathione, that contains a —SH group; a detection method using said fluorescent probe; and a detection kit containing said probe.[Solution] A fluorescent probe for detecting a compound containing an —SH group, wherein the fluorescent probe comprises a compound represented by formula (I) or a salt thereof (In the formula, X represents Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb), or O (wherein Ra and Rb each independently represent a hydrogen atom or alkyl group); R1 represents a hydrogen atom, or 1-4 identical or different substituents independently selected from the group consisting of a cyano group, alkyl group, carboxyl group, ester group, alkoxy group, amide group, and azide group, each of which may be optionally substituted; R2 represents a hydrogen atom, halogen atom, hydroxyl group, cyano group, or an alkyl group, alkynyl group, alkoxy group, aryl, or heteroaryl, each of which may be optionally substituted; R3 and R4 each independently represent a hydrogen atom or 1-3 identical or different substituents independently selected from the group consisting of a hydroxyl group, halogen atom, or an alkyl group, sulfo group, carboxyl group, ester group, amide group and azide group, each of which may be optionally substituted; R5, R6, R7 and R8 each independently represent a hydrogen atom or alkyl group, wherein, R5 or R6, respectively together with R3, may form a ring structure including the nitrogen atoms bonded thereto, or R7 or R8, respectively together with R4, may form a ring structure including the nitrogen atoms bonded thereto).
Public/Granted literature
- US20170045525A1 GLUTATHIONE-DETECTING FLUORESCENT PROBE Public/Granted day:2017-02-16
Information query
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