- 专利标题: 4-phenylpiperidines, their preparation and use
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申请号: US14775532申请日: 2014-03-13
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公开(公告)号: US10273243B2公开(公告)日: 2019-04-30
- 发明人: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- 申请人: The Trustees of Columbia University in the City of New York
- 申请人地址: US NY New York
- 专利权人: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址: US NY New York
- 代理机构: Cooper and Dunham LLP
- 代理商 John P. White; Gary J. Gershik
- 国际申请: PCT/US2014/026813 WO 20140313
- 国际公布: WO2014/152013 WO 20140925
- 主分类号: C07D498/04
- IPC分类号: C07D498/04 ; C07D471/04 ; C07D487/04 ; C07D495/04 ; C07D401/06 ; C07D405/14 ; C07D409/06 ; C07D491/052
摘要:
The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
公开/授权文献
- US20160046648A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE 公开/授权日:2016-02-18
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