Invention Grant
- Patent Title: Method of suppressing gene transcription through histone lysine methylation
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Application No.: US15003174Application Date: 2016-01-21
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Publication No.: US10280408B2Publication Date: 2019-05-07
- Inventor: Ming-ming Zhou , Shiraz Mujtaba
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C12N9/10 ; A61K38/43 ; C07K14/005 ; A61K48/00
Abstract:
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine mehtyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
Public/Granted literature
- US20160137989A1 METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION Public/Granted day:2016-05-19
Information query
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