An example method for predictive take-off rejection (TOR) of an aircraft includes receiving, at a computing device on the aircraft and at a time before the aircraft takes off for a current flight, outputs from a plurality of sensors positioned on the aircraft, comparing the outputs received from the plurality of sensors for the current flight to reference flight data, based on comparing the outputs received from the plurality of sensors for the current flight to the reference flight data the computing device making a determination of whether to initiate a TOR procedure before the aircraft reaches a takeoff speed on a runway, and based on determining to initiate the TOR procedure, the computing device sending a signal to a control device on the aircraft to initiate the TOR procedure.