Technologies for localized audio enhancement of a three-dimensional video include capturing a three-dimensional video including depth data using a three-dimensional camera of a mobile computing device and receiving a three-dimensional audio associated with the three-dimensional video using a microphone array. A user may enhance localized audio by selecting a region of the three-dimensional image from the three-dimensional video. In response, the mobile computing device generates an audio component of the three-dimensional audio corresponding to the selected region based on depth data associated with the selected region. A user may subsequently enhance the audio component by, for example, increasing the volume of the audio component or increasing the clarity of the audio component. In this way, a user may focus the audio playback on a selected portion of the three-dimensional video, which improves the user's ability to listen and understand an individual, group of individuals, or region captured in the three-dimensional video.