![3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof](/docs/US/2019-05-14/US10285982B2/abs.jpg.600x600.jpg)
- 专利标题： 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
-
申请号： US15749713申请日： 2016-08-03
-
公开(公告)号： US10285982B2公开(公告)日： 2019-05-14
- 发明人: Sunil Kumar KC , David Mark Wallace , Jianguo Cao , Chandramouli Chiruta , John Hood
- 申请人： Samumed, LLC
- 申请人地址： US CA San Diego
- 专利权人： Samumed, LLC
- 当前专利权人： Samumed, LLC
- 当前专利权人地址： US CA San Diego
- 代理机构： Fish & Richardson P.C.
- 国际申请： PCT/US2016/045261 WO 20160803
- 国际公布： WO2017/023980 WO 20170209
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; C07D519/00 ; A61P19/02 ; A61P11/00 ; A61P19/08 ; A61P35/00
![3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof](/abs-image/US/2019/05/14/US10285982B2/abs.jpg.150x150.jpg)
摘要：
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
公开/授权文献
信息查询
