公开(公告)号：US08883822B2

公开(公告)日：2014-11-11

申请号：US13887177

申请日：2013-05-03

申请人： Samumed, LLC ,  Samumed, LLC

发明人： John Hood ,  Sunil Kumar KC ,  David Mark Wallace

IPC分类号： C07D401/14 ,  A61K31/437

CPC分类号： A61K31/444 ,  A61K9/0019 ,  A61K9/0078 ,  A61K9/10 ,  A61K9/14 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07D401/14 ,  C07D471/04 ,  C07D519/00

摘要： Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

摘要翻译： 本文提供了根据式（I）或（II）的化合物及其药学上可接受的盐，以及包含其的组合物，用于各种方法，包括治疗癌症，异常细胞增殖，血管生成，阿尔茨海默氏病，肺病，骨关节炎， 特发性肺纤维化和神经病症/疾病/疾病。

公开(公告)号：US10899757B2

公开(公告)日：2021-01-26

申请号：US15773737

申请日：2016-11-07

申请人： Samumed, LLC

发明人： John Hood ,  David Mark Wallace ,  Sunil Kumar KC ,  Yusuf Yazici ,  Christopher Swearingen ,  Luis A Dellamary

IPC分类号： C07D471/04 ,  A61K31/444 ,  A61P19/02 ,  A61P29/00 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K9/00

摘要： Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

公开(公告)号：US20200325133A1

公开(公告)日：2020-10-15

申请号：US16710099

申请日：2019-12-11

申请人： Samumed, LLC

发明人： John Hood ,  David Mark Wallace ,  Sunil Kumar KC ,  Yusuf Yazici ,  Christopher Swearingen ,  Luis A Dellamary

IPC分类号： C07D471/04 ,  A61K31/444 ,  A61P19/02 ,  A61P29/00 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K9/00

摘要： Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

公开(公告)号：US10604512B2

公开(公告)日：2020-03-31

申请号：US15749587

申请日：2016-08-03

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： The present disclosure relates to indazole compounds having the following structure: or a pharmaceutically acceptable salt thereof, for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US10285982B2

公开(公告)日：2019-05-14

申请号：US15749713

申请日：2016-08-03

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： C07D471/04 ,  A61K31/437 ,  C07D519/00 ,  A61P19/02 ,  A61P11/00 ,  A61P19/08 ,  A61P35/00

摘要： 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US10166218B2

公开(公告)日：2019-01-01

申请号：US15749608

申请日：2016-08-03

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： A61K31/437 ,  C07D401/14 ,  A61P35/00 ,  A61P19/02 ,  A61P19/08 ,  A61P11/00

摘要： 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US20180325910A1

公开(公告)日：2018-11-15

申请号：US15843818

申请日：2017-12-15

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： A61K31/5377 ,  A61K31/506 ,  A61K31/497 ,  C07D519/00 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/437 ,  A61K31/496

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D519/00

摘要： Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US20180256588A1

公开(公告)日：2018-09-13

申请号：US15812629

申请日：2017-11-14

申请人： Samumed, LLC

发明人： John Hood ,  Sunil Kumar KC ,  David Mark Wallace

IPC分类号： A61K31/5377 ,  C07D519/00 ,  A61K31/415 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/444 ,  C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  C07D471/14 ,  C07D401/14

CPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  C07D401/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D519/00

摘要： Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof , and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

公开(公告)号：US10052331B2

公开(公告)日：2018-08-21

申请号：US15673834

申请日：2017-08-10

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： C07D401/14 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/506

CPC分类号： A61K31/5377 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07D519/00

摘要： Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US20180228782A1

公开(公告)日：2018-08-16

申请号：US15749713

申请日：2016-08-03

申请人： Samumed, LLC

发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

IPC分类号： A61K31/437 ,  A61P11/00 ,  A61P19/02 ,  A61P19/08 ,  A61P35/00

CPC分类号： A61K31/437 ,  A61P11/00 ,  A61P19/02 ,  A61P19/08 ,  A61P35/00 ,  C07D519/00

摘要： 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.