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128 条记录 (耗时 0.042 秒)

    3-(benzoimidazol-2-YL)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
    3.
    发明授权
    3-(benzoimidazol-2-YL)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof 有权

    公开(公告)号：US10654832B2

    公开(公告)日：2020-05-19

    申请号：US16252055

    申请日：2019-01-18

    申请人： Samumed, LLC

    发明人： Sunil Kumar KC ,  John Hood

    IPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

    Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors
    5.
    发明授权
    Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors 有权

    公开(公告)号：US10464924B2

    公开(公告)日：2019-11-05

    申请号：US15709057

    申请日：2017-09-19

    申请人： Samumed, LLC

    发明人： John Hood ,  Sunil Kumar KC

    IPC分类号： A61K31/416 ,  C07D401/14 ,  A61K45/06 ,  C07D401/10 ,  C07D405/14 ,  C07D413/12 ,  C07D401/04 ,  C07D401/12

    摘要： Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

    3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
    7.
    发明授权
    3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof 有权

    公开(公告)号：US10183929B2

    公开(公告)日：2019-01-22

    申请号：US15889403

    申请日：2018-02-06

    申请人： Samumed, LLC

    发明人： Sunil Kumar K C ,  John Hood

    IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.