Certain aspects involve selectively combining uplink transmissions in a distributed antenna system (“DAS”). For example, a unit of the DAS can receive baseband uplink transmissions from remote units of the DAS via a first channel and a second channel. The unit can generate a first combined uplink signal by combining baseband uplink transmissions received from a first subset of the remote units via the first channel that include data for transmission to a base station. The unit can generate a second combined uplink signal that includes baseband uplink transmissions received from a second subset of the remote units via the second channel and excludes or attenuates baseband uplink transmissions that are received from the first subset of the remote units via the second channel and that lack data for transmission to the base station are excluded or attenuated. The unit can transmit the combined uplink signals to the base station.