A processing system includes at least one central processing unit (CPU) core, at least one graphics processing unit (GPU) core, a main memory, and a coherence directory for maintaining cache coherence. The at least one CPU core receives a CPU cache flush command to flush cache lines stored in cache memory of the at least one CPU core prior to launching a GPU kernel. The coherence directory transfers data associated with a memory access request by the at least one GPU core from the main memory without issuing coherence probes to caches of the at least one CPU core.