Invention Grant
- Patent Title: Bacterium producing monophosphoryl lipid A and method of producing monophosphoryl lipid A by using bacterium
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Application No.: US15378681Application Date: 2016-12-14
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Publication No.: US10308945B2Publication Date: 2019-06-04
- Inventor: Hak Suk Chung , Eun Gyeong Yang , Dohyeon Hwang
- Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Seoul
- Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul
- Agency: Goldilocks Zone IP Law
- Priority: KR10-2016-0001708 20160106
- Main IPC: C12P19/12
- IPC: C12P19/12 ; C12N15/70 ; C12N9/10 ; C12N9/16 ; C12N15/52 ; C12N15/74
Abstract:
A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.
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