公开(公告)号：US10308945B2

公开(公告)日：2019-06-04

申请号：US15378681

申请日：2016-12-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk Chung ,  Eun Gyeong Yang ,  Dohyeon Hwang

IPC: C12P19/12 ,  C12N15/70 ,  C12N9/10 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.