Invention Grant
- Patent Title: Methods for reducing aggregate content of protein preparations by treatment with aryl anions
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Application No.: US15121655Application Date: 2014-02-27
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Publication No.: US10329322B2Publication Date: 2019-06-25
- Inventor: Peter Stanley Gagnon
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Applicant Address: SG Singapore
- Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee Address: SG Singapore
- Agency: Pillsbury Winthrop Shaw Pittman LLP
- International Application: PCT/SG2014/000085 WO 20140227
- International Announcement: WO2015/130221 WO 20150903
- Main IPC: C07K1/14
- IPC: C07K1/14 ; C07K1/32 ; C07K1/34 ; C07K1/36 ; B01D15/32 ; B01D15/36 ; B01D15/38 ; C07K16/00
Abstract:
A method of reducing the aggregate content in a preparation having a target protein includes contacting the preparation with an aryl anion to form a mixture and contacting the mixture with at least one electropositive solid to remove excess aryl anion.
Public/Granted literature
- US20160362447A1 METHODS FOR REDUCING AGGREGATE CONTENT OF PROTEIN PREPARATIONS BY TREATMENT WITH ARYL ANIONS Public/Granted day:2016-12-15
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