公开(公告)号：US20240360424A1

公开(公告)日：2024-10-31

申请号：US18683819

申请日：2022-08-17

申请人： Ultragenyx Pharmaceutical Inc.

发明人： Dennis Perry Chen ,  Wenjun Di ,  Chao Huang ,  Ying Cai ,  James C. Warren

IPC分类号： C12N7/00 ,  B01D15/36 ,  B01D15/42

CPC分类号： C12N7/00 ,  B01D15/363 ,  B01D15/426 ,  C12N2750/14123

摘要： Provided are methods of separating full capsid particles and empty capsid particles in a viral capsid preparation using an anion exchange medium. Methods may involve using a wash solution comprising a quaternary ammonium salt. Methods include applying a viral capsid preparation to an anion exchange medium, combined with multiple quaternary ammonium salt wash solutions.

公开(公告)号：US12122702B2

公开(公告)日：2024-10-22

申请号：US18094820

申请日：2023-01-09

申请人： SAMSUNG ELECTRONICS CO., LTD.

发明人： Jongha Yun ,  Seyoon Kim ,  Juhui Park ,  Jiyeon Lee ,  Cheolmin Shin

IPC分类号： C02F9/00 ,  B01D15/36 ,  B01D61/02 ,  B01D61/08 ,  B01D61/14 ,  B01D63/02 ,  B08B3/02 ,  B08B3/14 ,  B08B13/00 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  H01L21/67 ,  C02F103/04 ,  C02F103/34

CPC分类号： C02F9/00 ,  B01D15/361 ,  B01D61/02 ,  B01D61/025 ,  B01D61/026 ,  B01D61/08 ,  B01D61/14 ,  B01D63/02 ,  B08B3/022 ,  B08B3/14 ,  B08B13/00 ,  C02F1/283 ,  C02F1/42 ,  C02F1/441 ,  C02F1/444 ,  H01L21/67017 ,  B01D2313/083 ,  B01D2313/18 ,  B01D2313/60 ,  C02F2103/04 ,  C02F2103/346 ,  C02F2201/005 ,  C02F2209/03 ,  C02F2209/05 ,  C02F2209/40 ,  C02F2301/043 ,  C02F2301/046 ,  H01L21/67063 ,  H01L21/67092

摘要： Ultrapure water supply apparatuses, substrate processing systems, and substrate processing methods are provided. An ultrapure water supply apparatus includes: a first supply device that produces first ultrapure water; a second supply device that produces second ultrapure water; a first reserved supply device that provides the second supply device with a portion of fluid in the first supply device; and a second reserved supply device that provides the first supply device with a portion of fluid in the second supply device. The first supply device includes a first front-side filtering part, a first rear-side filtering part, and a first connection part. The second supply device includes a second front-side filtering part, a second rear-side filtering part, and a second connection part. Each of the first and second reserved supply devices connects the first connection part and the second connection part to each other.

公开(公告)号：US12109513B2

公开(公告)日：2024-10-08

申请号：US17260284

申请日：2019-05-22

申请人： WEST INVEST SA

发明人： Eric Reynaud ,  Eric Decanini

IPC分类号： B01D15/22 ,  B01D15/36 ,  B01J41/07 ,  B01J41/13 ,  B01J47/022 ,  B01J47/04 ,  G01N30/60

CPC分类号： B01D15/22 ,  B01D15/363 ,  B01J41/07 ,  B01J41/13 ,  B01J47/022 ,  B01J47/04 ,  G01N30/6069

摘要： A container for treating a fluid with an ion-exchange system is provided. The container includes a housing extending in an upright position between a bottom port and an opposed top port. The housing has an internal chamber. A bottom plate is disposed in the internal chamber above the bottom port and having a plurality of openings defined therethrough. The bottom plate divides the internal chamber between a main chamber and a bottom chamber. The bottom chamber is defined between the bottom plate and the bottom port. A plurality of diffusers extend from the bottom plate into the main chamber. Each one of the plurality of diffusers has a diffuser tube section projecting upwardly from the bottom plate and in fluid flow communication with the bottom chamber. The diffuser tube section has radial openings circumferentially distributed along a length thereof to radially discharge the fluid in the main chamber.

公开(公告)号：US12070702B2

公开(公告)日：2024-08-27

申请号：US17251869

申请日：2019-06-13

申请人： REGENXBIO INC.

发明人： Claire G. Zhang ,  Jeffrey Levine ,  Sara Zafar ,  Franz M. Gerner

IPC分类号： C12N7/00 ,  B01D15/16 ,  B01D15/36

CPC分类号： B01D15/363 ,  B01D15/166 ,  C12N7/00 ,  C12N2750/14123 ,  C12N2750/14151

摘要： Provided herein are methods for the purification of recombinant Adeno-Associated Virus (rAAV) particles using anion exchange chromatography.

公开(公告)号：US12060407B2

公开(公告)日：2024-08-13

申请号：US17025893

申请日：2020-09-18

申请人： Cytune Pharma

发明人： David Bechard ,  Guy De Martynoff

IPC分类号： C07K14/705 ,  B01D15/14 ,  B01D15/32 ,  B01D15/36 ,  B01J41/20 ,  C07K1/18 ,  C07K1/20 ,  C07K14/54 ,  C07K14/715 ,  A61K38/00

CPC分类号： C07K14/7155 ,  B01D15/14 ,  B01D15/327 ,  B01D15/363 ,  B01J41/20 ,  C07K1/18 ,  C07K1/20 ,  C07K14/5443 ,  A61K38/00 ,  C07K2319/00 ,  B01D15/363 ,  B01D15/327

摘要： The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.

公开(公告)号：US12053742B2

公开(公告)日：2024-08-06

申请号：US17506945

申请日：2021-10-21

申请人： Unger Marketing International, LLC

发明人： Kai Hirsch ,  Stephen Huda ,  Robert Camp ,  Paul H. Adams

IPC分类号： B01D61/02 ,  B01D15/36 ,  B01D35/143 ,  B01D61/04 ,  B01D61/08 ,  B01D61/12 ,  C02F1/00 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F5/00

CPC分类号： B01D61/025 ,  B01D15/361 ,  B01D35/1435 ,  B01D61/029 ,  B01D61/04 ,  B01D61/08 ,  B01D61/12 ,  C02F1/001 ,  C02F1/008 ,  C02F1/441 ,  C02F5/00 ,  B01D2201/301 ,  B01D2201/347 ,  B01D2201/4076 ,  B01D2311/14 ,  B01D2311/246 ,  B01D2311/2623 ,  B01D2311/2649 ,  B01D2313/02 ,  B01D2313/041 ,  B01D2313/125 ,  B01D2313/206 ,  B01D2313/21 ,  B01D2313/24 ,  B01D2313/44 ,  B01D2317/04 ,  C02F1/283 ,  C02F1/42 ,  C02F2201/004 ,  C02F2201/006 ,  C02F2201/008 ,  C02F2209/003 ,  C02F2209/008 ,  C02F2209/03 ,  C02F2209/10 ,  C02F2307/06 ,  Y02W10/37

摘要： A portable water conditioning system is provided that includes an incoming water inlet; a reverse osmosis stage in fluid communication with the incoming water inlet, the reverse osmosis stage having a permeate outlet and a concentrate outlet; a diversion device having a diversion valve, the diversion valve placing the concentrate outlet in fluid communication with a waste water outlet; a deionizing stage in fluid communication with a pure water outlet; a bypass valve configured to selectively place the permeate outlet in fluid communication with one or more of the waste water outlet, the deionizing stage, and the pure water outlet; and a controller configured to control the diversion device and the bypass valve to provide water at the pure water outlet of a desired condition.

公开(公告)号：US20240251826A1

公开(公告)日：2024-08-01

申请号：US17280313

申请日：2019-10-02

申请人： West Invest SA

发明人： Stanislas Baudouin ,  Eric Reynaud

IPC分类号： A23L2/78 ,  A23L2/04 ,  A23L2/08 ,  B01D15/18 ,  B01D15/36 ,  B01J39/05 ,  B01J39/16 ,  B01J39/26

CPC分类号： A23L2/78 ,  A23L2/04 ,  A23L2/08 ,  B01D15/185 ,  B01D15/362 ,  B01J39/05 ,  B01J39/16 ,  B01J39/26

摘要： This disclosure relates to an proanthocyanidin extract, extract comprising sugars of a fruit juice processes for preparing same as well as the use of the extract or a composition thereof as food or neutraceutical composition.

公开(公告)号：US20240230602A9

公开(公告)日：2024-07-11

申请号：US17969779

申请日：2022-10-20

申请人： Dionex Corporation

发明人： Mrinal K. Sengupta ,  George Tang ,  Husam Al-Esawi

IPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/36 ,  B01D15/42 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64

CPC分类号： G01N30/14 ,  B01D15/24 ,  B01D15/361 ,  B01D15/424 ,  B01D61/46 ,  G01N30/32 ,  G01N30/64 ,  G01N2030/027

摘要： Systems and methods are described for ion chromatography systems and electrolytic suppressors. By varying the operating frequency of an electrolytic suppressor, the generation of bubbles and noise can be minimized. This leads to more accurate results in e.g., a conductivity detector downstream of an electrolytic suppressor within an ion chromatography system. In certain embodiments, it has been found that frequencies of around 700-750 Hz, 100-150 Hz and 925-975 Hz have achieved the best results.

公开(公告)号：US20240207759A1

公开(公告)日：2024-06-27

申请号：US18514367

申请日：2023-11-20

申请人： Drops Tech 2015 Ltd

发明人： Baruch ZISER

IPC分类号： B01D15/18 ,  B01D15/22 ,  B01D15/36 ,  B01D61/18 ,  C02F1/28 ,  C02F1/44

CPC分类号： B01D15/18 ,  B01D15/22 ,  B01D15/361 ,  B01D61/18 ,  C02F1/281 ,  C02F1/283 ,  C02F1/444 ,  B01D2313/083 ,  B01D2313/44 ,  C02F2201/006 ,  C02F2301/043

摘要： A water treatment system comprising filter and filter head is provided. The filter comprises: a cartridge; a cap attached to the cartridge; the cartridge comprises: first compartment comprising first water-treating medium/s; second compartment comprising second water-treating medium/s; the cap comprises a selector. The filter further comprises bypass/es extending from the selector and throughout first compartment and into second compartment, each of the bypass/es having an inlet and an outlet. In first state all water entering the filter passes through the first compartment; in second state all water entering the filter bypasses first compartment and passes through second compartment. In intermediate state/s first part of water enters the filter passing through the first compartment and a second part of water enters the filter bypassing the first compartment and passes through the second compartment. The filter head is reversibly attachable to the cap.

公开(公告)号：US12018075B2

公开(公告)日：2024-06-25

申请号：US16389055

申请日：2019-04-19

申请人： Janssen Biotech, Inc.

发明人： Paul Randolph

IPC分类号： C07K16/24 ,  B01D15/16 ,  B01D15/20 ,  B01D15/36 ,  B01D15/38 ,  C07K1/18 ,  C07K1/22 ,  G01N30/56 ,  G01N30/86 ,  G01N35/00

CPC分类号： C07K16/244 ,  B01D15/166 ,  B01D15/20 ,  B01D15/206 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3809 ,  C07K1/18 ,  C07K1/22 ,  C07K16/241 ,  G01N30/56 ,  G01N30/8665 ,  G01N35/00623 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  G01N2030/562

摘要： A method of operating a chromatography column is described for use in methods of manufacture for producing anti-TNF antibodies, e.g., the anti-TNFα antibody SIMPONI® (golimumab). This method involves collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during operation of the chromatography column comprising column packing. A model gamma cumulative distribution curve is calculated based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front. A height equivalent theoretical plate (HETP) value is calculated for the at least one mobile phase transition front using parameters of the model gamma cumulative distribution curve and the quality of the chromatography column packing is assessed based on the calculated HETP value.