- 专利标题： Neprilysin inhibitors
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申请号： US15806680申请日： 2017-11-08
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公开(公告)号： US10336773B2公开(公告)日： 2019-07-02
- 发明人: Roland Gendron , Adam D. Hughes
- 申请人： THERAVANCE BIOPHARMA R&D IP, LLC
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人： THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah
- 主分类号： C07D498/08
- IPC分类号： C07D498/08 ; C07D249/08 ; C07D263/56 ; C07D233/26 ; C07D233/90 ; C07D237/24 ; C07D249/18 ; C07D261/18 ; C07D263/34 ; C07D271/06 ; C07D277/56 ; C07D333/70 ; C07D401/06 ; C07D403/06 ; C07D409/06 ; C07D498/04 ; C07D239/36 ; C07D413/06 ; A61K31/42 ; C07D231/14 ; C07D213/81 ; C07D239/34 ; C07D241/24 ; C07D249/04 ; C07D249/10 ; C07D257/04 ; C07D261/20 ; C07D307/68 ; C07D401/04 ; C07D403/04 ; C07D405/12 ; C07D471/04 ; C07D207/34 ; A61K31/422 ; A61K31/5377 ; A61K45/06 ; C07D413/04 ; C07D413/12 ; C07D213/79 ; C07D213/80 ; C07D237/04 ; C07D249/12 ; C07D261/12 ; C07D277/46 ; C07D333/40
摘要：
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
公开/授权文献
- US20180194776A1 NEPRILYSIN INHIBITORS 公开/授权日：2018-07-12
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