Invention Grant
- Patent Title: Recombinant IgG4 monovalent antibodies
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Application No.: US15072983Application Date: 2016-03-17
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Publication No.: US10351629B2Publication Date: 2019-07-16
- Inventor: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
- Applicant: GENMAB A/S
- Applicant Address: DK Copenhagen V
- Assignee: GENMAB A/S
- Current Assignee: GENMAB A/S
- Current Assignee Address: DK Copenhagen V
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Christopher L. Frank
- Priority: DKPA200700795 20070531
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/00 ; C12N15/85 ; C07K16/28
Abstract:
The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Public/Granted literature
- US20170037138A1 TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS Public/Granted day:2017-02-09
Information query
