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公开(公告)号：US20230374131A1
公开(公告)日：2023-11-23
申请号：US18109708
申请日：2023-02-14
Applicant: Genmab A/s
Inventor： Edward Norbert VAN DEN BRINK , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
CPC classification number: C07K16/2809 , C07K16/2887 , C07K16/32 , C07K16/1063 , C07K16/2863 , C07K16/2896 , C07K16/4241 , G01N33/6872 , A61K2039/505
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US11046771B2
公开(公告)日：2021-06-29
申请号：US15832366
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US10906991B2
公开(公告)日：2021-02-02
申请号：US14934956
申请日：2015-11-06
Applicant: GENMAB A/S
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Rob Aalberse , Marijn Van Der Neut Kolfschote , Paul Parren
Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.
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公开(公告)号：US20180319888A1
公开(公告)日：2018-11-08
申请号：US15977725
申请日：2018-05-11
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Lasters
IPC: C07K16/28 , C07K16/00 , A61K47/68 , A61K51/10 , A61K39/395
CPC classification number: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
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公开(公告)号：US20150376282A1
公开(公告)日：2015-12-31
申请号：US14739768
申请日：2015-06-15
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Laster
IPC: C07K16/28 , A61K47/48 , A61K51/10 , A61K39/395
CPC classification number: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
Abstract translation: 本发明涉及抗体的恒定区，特别是IgG4的CH3区的位置，其影响了CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。
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Patent Agency Ranking
6.发明授权公开(公告)号：US11932693B2
公开(公告)日：2024-03-19
申请号：US18315686
申请日：2023-05-11
Applicant: BioNTech SE , Genmab A/S
Inventor： Ugur Sahin , Sina Fellermeier-Kopf , Friederike Gieseke , Karsten Beckmann , Claudia Paulmann , Alexander Muik , Ivan Kuzmanov , Esther Cornelia Wilhelmina Breij , Patricia Garrido Castro , Jordan Blum , Lars Guelen , Joost Neijssen , Bart-Jan De Kreuk , Richard Hibbert , Janine Schuurman , Aran Frank Labrijn
IPC: C07K16/28
CPC classification number: C07K16/2818 , C07K2317/24 , C07K2317/92
Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.
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公开(公告)号：US20230227495A1
公开(公告)日：2023-07-20
申请号：US17939736
申请日：2022-09-07
Applicant: Genmab A/S
Inventor： Michael GRAMER , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kampen , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Amout F. Gerritsen
CPC classification number: C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：US11492371B2
公开(公告)日：2022-11-08
申请号：US16426647
申请日：2019-05-30
Applicant: GENMAB A/S
Inventor： Michael Gramer , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kampen , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Arnout F. Gerritsen
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：US11359015B2
公开(公告)日：2022-06-14
申请号：US15744317
申请日：2016-07-14
Applicant: GENMAB A/S
Inventor： Rik Rademaker , Isil Altintas , Patrick Engelberts , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US10597464B2
公开(公告)日：2020-03-24
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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