A method and apparatus for timing advance (TA) synchronization for uplink (UL) data transmissions are provided. A base station transmits a TA instruction to a UE. The TA instruction indicates one of at least two TA options. The first TA option indicates direct initial grant-free (GF) uplink (UL) data transmissions. The second TA option indicates indirect initial GF UL data transmissions with the UE initiating TA reference signaling for updating a TA parameter of the UE. The UE performs an initial GF UL data transmission to the base station based on the TA instruction.