发明授权
- 专利标题: (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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申请号: US14814580申请日: 2015-07-31
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公开(公告)号: US10363251B2公开(公告)日: 2019-07-30
- 发明人: Bobby N. Trawick , David W. Berberich , Christopher W. Grote
- 申请人: Mallinckrodt LLC
- 申请人地址: US MO Hazelwood
- 专利权人: Mallinckrodt LLC
- 当前专利权人: Mallinckrodt LLC
- 当前专利权人地址: US MO Hazelwood
- 主分类号: A61K31/485
- IPC分类号: A61K31/485 ; A61K31/167 ; A61K31/472 ; C07D217/20 ; C07D221/28 ; C07D489/00 ; C07D489/02 ; C07D489/08 ; C07D489/10 ; A61K45/06
摘要:
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat a variety of disorders.
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