A VA liquid crystal display panel based on BM-less technology and a manufacturing method thereof are provided. The VA liquid crystal display panel based on BM-less technology includes a color mixture prevention zone that is formed of a stacked arrangement of red color resist and blue color resist and is used in combination with a main photo spacer and a sub photo spacer that are formed of a black material as a substitute of a black matrix. Further, the color mixture prevention zone has a portion that corresponds to the main photo spacer and the sub photo spacer and includes a recess formed therein. The main photo spacer is in engagement with a bottom of the recess to increase a height difference between the main photo spacer and the sub photo spacer and thus expanding LC margin and ensuring product yield rate.