Methods and systems for split voltage domain transmitter circuits are disclosed and may include a two-branch output stage including a plurality of CMOS transistors, each branch of the two-branch output stage comprising two stacked CMOS inverter pairs from among the plurality of CMOS transistors; the two stacked CMOS inverter pairs of a given branch being configured to drive a respective load, in phase opposition to the other branch; and a pre-driver circuit configured to receive a differential modulating signal and output, to respective inputs of the two stacked CMOS inverters, two synchronous differential voltage drive signals having a swing of half the supply voltage and being DC-shifted by half of the supply voltage with respect to each other. The load may include a series of diodes that are driven in differential mode via the drive signals. An optical signal may be modulated via the diodes.