Invention Grant
- Patent Title: Benzopiperazine compositions as BET bromodomain inhibitors
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Application No.: US16029166Application Date: 2018-07-06
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Publication No.: US10377769B2Publication Date: 2019-08-13
- Inventor: Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Adam C. Talbot , Mark J. Tebbe
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: Forma Therapeutics, Inc.
- Current Assignee: Forma Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent Michael A. Shinall; Erica M. D'Amato
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; A61K31/4985 ; A61K31/53 ; C07D401/04 ; C07D401/06 ; C07D401/10 ; C07D401/12 ; C07D403/04 ; C07D403/06 ; C07D403/10 ; C07D403/14 ; C07D405/04 ; C07D405/06 ; C07D405/10 ; C07D405/12 ; C07D409/06 ; C07D409/12 ; C07D409/14 ; C07D413/04 ; C07D413/06 ; C07D413/12 ; C07D417/04 ; C07D417/06 ; C07D241/42 ; C07D417/10 ; C07D241/50 ; C07D417/14 ; C07D451/04 ; C07D471/04 ; C07D487/04 ; C07D487/08 ; C07D491/048 ; C07D495/04 ; A61K45/06 ; A61K31/498 ; A61K31/5025 ; A61K31/519 ; A61K31/5377 ; A61K31/541 ; A61K31/551 ; A61K31/506 ; A61K31/517 ; A61K31/55 ; A61K31/553
Abstract:
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
Public/Granted literature
- US20180312524A1 BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS Public/Granted day:2018-11-01
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