Invention Grant
- Patent Title: Three-dimensional silk fibroin scaffold culture retaining functional salivary cells and promoting salivary tissue-specific ECM synthesis
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Application No.: US15118539Application Date: 2015-02-09
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Publication No.: US10377986B2Publication Date: 2019-08-13
- Inventor: Xiao-Dong Chen , Chih-ko Yeh , Joo L. Ong
- Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbrignt US LLP
- International Application: PCT/US2015/014994 WO 20150209
- International Announcement: WO2015/123132 WO 20150820
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A61L27/38 ; A61L27/22
Abstract:
A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells. The cell culture system can be used to produce a salivary tissue-specific extracellular matrix capable of inducing differentiation of salivary gland cell precursors into salivary gland cells.
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