Techniques may be used for interference measurement and management in directional mesh networks, including centralized and/or distributed approaches. A centralized node, such as an operations and maintenance (OAM) center, may use feedback from nodes in the mesh network to partition the nodes in the mesh network into clusters based on interference levels. Interference measurement reports may be used by the centralized node to update cluster membership. An initiating node in the mesh network may use topographical information to generate an initial interference cluster, and interference measurement frame (IMF) scheduling information may be used to schedule transmissions within the interference clusters. Techniques for opportunistic measurement campaigns, simultaneous measurement campaigns, link failure detection, and link re-acquisition in directional mesh networks may also be used.