Invention Grant
- Patent Title: Bifunctional cytotoxic agents
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Application No.: US16053344Application Date: 2018-08-02
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Publication No.: US10391182B2Publication Date: 2019-08-27
- Inventor: Andreas Maderna , Matthew David Doroski , Zecheng Chen , Hud Lawrence Risley , Jeffrey Michael Casavant , Christopher John O'Donnell , Alexander M. Porte , Chakrapani Subramanyam
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent David Rubin
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D487/06 ; A61K47/68 ; A61K31/404 ; A61K31/407 ; A61K31/433 ; A61K31/4439 ; A61K31/454 ; A61K31/675 ; A61K31/7056 ; A61K38/05 ; A61K38/06 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D417/14 ; C07F9/6561 ; C07H17/02 ; C07K5/06 ; C07K5/08 ; C07K9/00
Abstract:
Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
Public/Granted literature
- US20180339060A1 BIFUNCTIONAL CYTOTOXIC AGENTS Public/Granted day:2018-11-29
Information query
