Invention Grant
- Patent Title: High functional enzyme having modified substrate specificity of human β-hexosaminidase B and exhibiting protease resistance
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Application No.: US14436833Application Date: 2013-10-17
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Publication No.: US10400226B2Publication Date: 2019-09-03
- Inventor: Koji Ito , Hitoshi Sakuraba , Daisuke Tsuji
- Applicant: TOKUSHIMA UNIVERSITY , MEIJI PHARMACEUTICAL UNIVERSITY
- Applicant Address: JP Tokushima-Shi, Tokushima JP Kiyose-Shi, Tokyo
- Assignee: TOKUSHIMA UNIVERSITY,MEJI PHARMACEUTICAL UNIVERSITY
- Current Assignee: TOKUSHIMA UNIVERSITY,MEJI PHARMACEUTICAL UNIVERSITY
- Current Assignee Address: JP Tokushima-Shi, Tokushima JP Kiyose-Shi, Tokyo
- Agency: Brinks Gilson & Lione
- Priority: JP2012-232266 20121019
- International Application: PCT/JP2013/078179 WO 20131017
- International Announcement: WO2014/061735 WO 20140424
- Main IPC: C12N9/24
- IPC: C12N9/24 ; A61K38/47 ; A61K38/00
Abstract:
Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.
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