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公开(公告)号：US10400226B2
公开(公告)日：2019-09-03
申请号：US14436833
申请日：2013-10-17
Applicant: TOKUSHIMA UNIVERSITY , MEIJI PHARMACEUTICAL UNIVERSITY
Inventor： Koji Ito , Hitoshi Sakuraba , Daisuke Tsuji
Abstract: Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.
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