-
公开(公告)号:US20240327828A1
公开(公告)日:2024-10-03
申请号:US18743751
申请日:2024-06-14
Applicant: Tokushima University
Inventor: Keishi Osakabe , Yuriko Osakabe
CPC classification number: C12N15/111 , C12N9/22 , C12N15/102 , C12N2310/20
Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.
-
公开(公告)号:US12064460B2
公开(公告)日:2024-08-20
申请号:US16964142
申请日:2019-01-25
Applicant: TOKUSHIMA UNIVERSITY , JICHI MEDICAL UNIVERSITY , GENE THERAPY RESEARCH INSTITUTION CO., LTD.
Inventor: Kohji Itoh , Daisuke Tsuji , Shinichi Muramatsu , Katsuhito Asai
CPC classification number: A61K35/76 , A61P25/28 , C12N7/00 , C12N2750/14121 , C12N2750/14143 , C12N2750/14171
Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.
-
3.
公开(公告)号:US20230221298A1
公开(公告)日:2023-07-13
申请号:US18009429
申请日:2021-06-10
Applicant: Tokushima University
Inventor: Hideharu ABE , Koichi UTE
IPC: G01N33/493 , G01N33/68 , G01N33/53 , B01J20/26 , B01J20/28
CPC classification number: G01N33/493 , B01J20/261 , B01J20/267 , B01J20/28004 , G01N33/5308 , G01N33/6803 , B01J2220/68
Abstract: Provided is a method for simply obtaining a desired size fraction from an aqueous sample containing particles. The method includes the following steps: (1) bringing the aqueous sample containing particles into contact with a superabsorbent polymer to obtain a superabsorbent polymer gel containing a portion of the particles, and (2) mixing the superabsorbent polymer gel with a salt to recover a portion of the particles.
-
公开(公告)号:US20230124208A1
公开(公告)日:2023-04-20
申请号:US17905486
申请日:2021-03-04
Applicant: TOKUSHIMA UNIVERSITY , FUJIKIN INCORPORATED
Inventor: Yoshihiro DEGUCHI , Masaaki NAGASE , Kouji NISHINO , Nobukazu IKEDA
IPC: G01N21/27 , G01N21/3504 , G01N21/31
Abstract: A concentration measurement method performed in a concentration measurement device including an electric unit having a light source and a photodetector, a fluid unit having a measurement cell through which a gas flows, and a processing circuit for calculating a concentration of the gas based on an intensity of a light passing through the measurement cell. The concentration measurement method includes a step of determining an absorption coefficient of the measurement gas using a reference absorption coefficient determined in association with the reference gas and a correction factor associated with the measurement gas, and a step of obtaining a concentration of the measurement gas flowing in the measurement cell using the absorption coefficient of the measurement gas. When the absorption peak wavelength of the measurement gas is longer than the peak wavelength of the light source, a reference gas having a longer absorption peak wavelength than the peak wavelength of the light source is used, and when the absorption peak wavelength of the measurement gas is shorter than the peak wavelength of the light source, a reference gas having a shorter absorption peak wavelength than the peak wavelength of the light source is used.
-
公开(公告)号:US10976240B2
公开(公告)日:2021-04-13
申请号:US15748264
申请日:2016-08-09
Applicant: TOKUSHIMA UNIVERSITY , FUJIKIN INCORPORATED
Inventor: Yoshihiro Deguchi , Masaaki Nagase , Michio Yamaji , Nobukazu Ikeda , Kouji Nishino , Masayoshi Kawashima , Kazuteru Tanaka
IPC: G01N21/94 , G01N21/31 , G01N21/33 , G01N21/27 , G01J3/10 , G01J3/42 , G01N21/59 , G01N21/15 , G01N21/55 , G01N21/88
Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.
-
公开(公告)号:US10384998B2
公开(公告)日:2019-08-20
申请号:US16202914
申请日:2018-11-28
Applicant: Mitsubishi Chemical Corporation , TOKUSHIMA UNIVERSITY
Inventor: Yuki Kato , Wataru Ninomiya , Shigeru Sugiyama
Abstract: To provide a method for producing propionaldehyde directly from glycerol with high yield, gasified glycerol is brought into contact with a silica-type regular mesoporous body. More specifically, gasified glycerol is supplied to a catalyst layer containing a regular mesoporous body while heating the catalyst layer at a temperature ranging from 200 to 800° C. in such a manner that a W/F value can fall within the range from 0.001 to 1000 g·min/ml inclusive wherein W represents an amount (g) of a catalyst and F represents a supply rate (ml/min) of supplied glycerol.
-
公开(公告)号:US10302563B2
公开(公告)日:2019-05-28
申请号:US14913296
申请日:2014-08-21
Applicant: Tokushima University
Inventor: Yoshihiro Deguchi , Takahiro Kamimoto
IPC: G01N21/61 , G01N21/3504 , G01J3/427 , G01N21/31 , G01N21/39 , G01J5/00 , G01J3/433 , G01J5/60 , G01K11/18 , G01K11/00
Abstract: A gas analyzing apparatus includes first and second laser sources that output first and second laser lights, a laser controller that controls the first and second laser sources to vary wavelengths of the first and second laser lights in the respective predetermined wavelength ranges, an optical multiplexer that multiplexes the first and second laser lights to transmit the multiplexed laser light to a target gas, an optical receiver that receives the laser light transmitted through the target gas, and an analyzer that analyzes a temperature and/or a concentration of the target gas based on an electric signal output from the optical receiver. While varying the wavelengths of the laser lights, the laser controller controls amplitudes of the first and second laser lights to differ from each other and varies intensities of the first and second laser lights in the opposite direction.
-
公开(公告)号:US20190135722A1
公开(公告)日:2019-05-09
申请号:US16202914
申请日:2018-11-28
Applicant: Mitsubishi Chemical Corporation , TOKUSHIMA UNIVERSITY
Inventor: Yuki Kato , Wataru Ninomiya , Shigeru Sugiyama
CPC classification number: C07C45/511 , B01J29/035 , B01J29/041 , B01J35/10 , C07C45/52 , C07C47/02
Abstract: To provide a method for producing propionaldehyde directly from glycerol with high yield, gasified glycerol is brought into contact with a silica-type regular mesoporous body. More specifically, gasified glycerol is supplied to a catalyst layer containing a regular mesoporous body while heating the catalyst layer at a temperature ranging from 200 to 800° C. in such a manner that a W/F value can fall within the range from 0.001 to 1000 g·min/ml inclusive wherein W represents an amount (g) of a catalyst and F represents a supply rate (ml/min) of supplied glycerol.
-
公开(公告)号:US10222323B2
公开(公告)日:2019-03-05
申请号:US15321398
申请日:2015-07-23
Applicant: TOKUSHIMA UNIVERSITY , FUJIKIN INCORPORATED
Inventor: Yoshihiro Deguchi , Masaaki Nagase , Nobukazu Ikeda , Michio Yamaji , Tadayuki Yakushijin
Abstract: An inline concentration measurement device comprises: a measurement cell main body with a gas flow path formed; a light incident part with a window member connected to the main body; and a light receiving part with a window member connected to the main body, wherein the gas flow path includes a gas flow path for an optical path extending straight between the window members of the light incident part and the light receiving part, a first communication part making a gas inlet formed in the main body communicate with the gas flow path part for the optical path, and a second communication part making a gas outlet formed in the main body communicate with the gas flow path part for the optical path, and the first communication part obliquely extends from the gas inlet towards the window member of the light incident part.
-
公开(公告)号:US20180325946A1
公开(公告)日:2018-11-15
申请号:US16043395
申请日:2018-07-24
Applicant: Tokushima University
Inventor: Minoru Ueda , Yoichi Yamada , Katsumi Ebisawa , Akihito Yamamoto , Kiyoshi Sakai , Kohki Matsubara , Hisashi Hattori , Masahiko Sugiyama , Takanori Inoue
IPC: A61K35/12 , A61K38/30 , A61K35/545 , A61K38/18 , C12N5/0775 , A61K35/32 , A61K35/28 , A61K35/30
CPC classification number: A61K35/12 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/545 , A61K38/18 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/30 , C12N5/0664 , A61K2300/00
Abstract: The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.
-
-
-
-
-
-
-
-
-