- 专利标题： Thiourea derivatives as activators of RORα and pharmaceutical composition containing same
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申请号： US15759588申请日： 2012-05-23
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公开(公告)号： US10407388B2公开(公告)日： 2019-09-10
- 发明人: Mi Ock Lee , Hyeung Geun Park , Eun Jin Kim , Ho Young Son , Hyo Jun Jung , Suck Chang Hong , Tae Young Na
- 申请人： Mi Ock Lee , Hyeung Geun Park , Eun Jin Kim , Ho Young Son , Hyo Jun Jung , Suck Chang Hong , Tae Young Na
- 申请人地址： KR Seoul
- 专利权人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
- 当前专利权人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
- 当前专利权人地址： KR Seoul
- 代理机构： Vorys, Sater, Seymour & Pease LLP
- 代理商 Mih Suhn Koh
- 优先权： KR10-2011-0048455 20110523; KR10-2011-0128903 20111205; KR10-2012-0054540 20120523
- 国际申请： PCT/KR2012/004081 WO 20120523
- 国际公布： WO2012/161518 WO 20121129
- 主分类号： C07C335/12
- IPC分类号： C07C335/12 ; A61P9/10 ; A61P1/16 ; A61P3/06 ; A61P29/00
摘要：
Provided is a compound activating RORα gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.
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