专利检索 ipc:"C07C335/12" 第 1 页

1.

发明授权
Capsazepine analogs for the treatment of cancer and other proliferative diseases 有权

公开(公告)号：US10457676B2

公开(公告)日：2019-10-29

申请号：US15505260

申请日：2015-08-25

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Cara B. Gonzales , Stanton McHardy

IPC分类号： C07D471/04 , A61K31/55 , C07D233/16 , A61K31/472 , C07D209/44 , A61K31/5377 , C07D213/68 , A61K31/4745 , A61K31/17 , A61K45/06 , A61K31/155 , A61K31/165 , A61K31/4035 , C07D217/06 , C07D223/16 , C07C275/24 , C07C211/29 , C07C335/12 , C07C233/29 , A61P35/00

摘要： The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.

2.

发明授权
Thiourea derivatives as activators of RORα and pharmaceutical composition containing same 有权

公开(公告)号：US10407388B2

公开(公告)日：2019-09-10

申请号：US15759588

申请日：2012-05-23

申请人： Mi Ock Lee , Hyeung Geun Park , Eun Jin Kim , Ho Young Son , Hyo Jun Jung , Suck Chang Hong , Tae Young Na

发明人： Mi Ock Lee , Hyeung Geun Park , Eun Jin Kim , Ho Young Son , Hyo Jun Jung , Suck Chang Hong , Tae Young Na

IPC分类号： C07C335/12 , A61P9/10 , A61P1/16 , A61P3/06 , A61P29/00

摘要： Provided is a compound activating RORα gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.

3.

发明授权
Compositions, apparatus, systems, and methods for resolving electronic excited states 有权

公开(公告)号：US09765051B2

公开(公告)日：2017-09-19

申请号：US14792431

申请日：2015-07-06

申请人： HALLSTAR INNOVATIONS CORP.

发明人： Craig A. Bonda , Shengkui Hu , Qing Jean Zhang , Zhihui Zhang

IPC分类号： C07C255/41 , C07C69/618 , C07C335/12 , C07D335/12 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/49 , A61K41/00 , A61K47/14 , A61K47/16 , A61K47/22 , A61Q17/04 , C07C255/34 , C07C255/40 , C07C325/04 , C07C327/22 , C07D311/82

CPC分类号： C07D335/12 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/494 , A61K8/498 , A61K8/4986 , A61K41/0071 , A61K47/14 , A61K47/16 , A61K47/22 , A61K2800/522 , A61Q17/04 , C07C69/618 , C07C255/34 , C07C255/40 , C07C255/41 , C07C325/04 , C07C327/22 , C07C2603/18 , C07C2603/24 , C07D311/82 , Y10T428/249921

摘要： The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state energy from other molecules (e.g., light-absorbing molecules) or directly from the irradiation sources. According to some embodiments, the disclosure relates to molecules, including conjugated fused polycyclic molecules, that may resolve (e.g., quench, dissipate) excited state energy, normally by way of releasing it as heat. (e.g., as heat). Conjugated fused polycyclic molecules of various structures are disclosed including Formula III: The disclosure further relates to methods of use and/or therapy using molecules of Formulas I, II, and/or III.

4.

发明授权
Co-crystal production method 有权

公开(公告)号：US09635856B2

公开(公告)日：2017-05-02

申请号：US15103925

申请日：2014-12-10

申请人： Nippon Soda Co., Ltd.

发明人： Satoru Yamamura

IPC分类号： C07D249/04 , C07D249/08 , C07C335/12 , A01N43/653 , A01N47/34

CPC分类号： A01N43/653 , A01N47/34 , C07C335/12 , C07D249/08 , A01N25/12

摘要： The present invention provides a method for producing a co-crystal including thiophanate-methyl and a triazole-based compound such as tebuconazole and a method for producing an agricultural and horticultural chemical preparation using the co-crystal as a raw material. As one example, the agricultural and horticultural chemical preparation can be obtained by a method including the steps of obtaining a sol including a co-crystal by stirring a suspension including thiophanate-methyl, a triazole compound such as a tebuconazole, a surfactant, a defoaming agent and water at a mixing degree of 0.1-1.0 while holding the temperature of the suspension at 60° C.; and adding auxiliary components such as silica, calcium carbonate and the like to the sol.

5.

发明授权
Method of photostabilizing UV absorbers, particularly dibenzyolmethane derivatives, e.g., Avobenzone, with cyano-containing fused tricyclic compounds 有权
标题翻译： UV稳定剂的方法，特别是二苯甲烷甲烷衍生物，如阿伏苯宗，含氰基的稠合三环化合物

公开(公告)号：US09125829B2

公开(公告)日：2015-09-08

申请号：US13588662

申请日：2012-08-17

申请人： Craig A. Bonda , Shengkui Hu

发明人： Craig A. Bonda , Shengkui Hu

IPC分类号： C07C255/41 , C07C69/618 , C07C335/12 , A61K8/40 , A61Q17/04 , A61K8/49

CPC分类号： A61K8/40 , A61K8/498 , A61K8/4986 , A61Q17/04

摘要： A photostabilized photoactive composition comprising a mixture of a photoactive compound that develops a singlet excited state, or fluoresces when subjected to UV radiation and an effective amount of an excited state quencher comprising a cyano-containing fused tricyclic compound of formula (I): wherein: A is selected from the group consisting of O, S, C═O, and n is selected from the group consisting of 0 and 1; and, R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, ether, aryl, and amino.

摘要翻译： 包含形成单重激发态的光活性化合物的混合物或经受紫外线辐射时发荧光的有光稳定的光活性组合物和有效量的包含含氰基的式（I）的稠合三环化合物的激发态猝灭剂：其中： A选自O，S，C = O，n选自0和1; 并且R 1和R 2各自独立地选自烷基，环烷基，醚，芳基和氨基。

6.

发明申请
Cdc42 Inhibitor and Uses Thereof 审中-公开
标题翻译： Cdc42抑制剂及其用途

公开(公告)号：US20140194451A1

公开(公告)日：2014-07-10

申请号：US14087662

申请日：2013-11-22

申请人： Qun Lu , Huchen Zhou , Yanhua Chen , Amy Friesland

发明人： Qun Lu , Huchen Zhou , Yanhua Chen , Amy Friesland

IPC分类号： C07D239/42 , C07C335/12

CPC分类号： C07D239/42 , C07C335/12 , C07D239/69

摘要： Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit, the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.

摘要翻译： 提供抑制小G蛋白Rho GTPase细胞分裂周期蛋白Cdc42的化合物。丝状伪足，Ccd42磷酸化的蛋白质印迹以及对细胞伤口愈合和对生长锥形成的影响的形态学分析都证明所述化合物能够抑制所有测试的Cdc42介导的过程。这些化合物有效抑制Cdc42的作用，并有效抑制涉及肌动蛋白的Cdc42相关细胞功能，如高尔基体组织和细胞运动。此外，所述Cdc42抑制剂化合物可以作为治疗各种病症的药物提供。

7.

发明授权
3-Methoxybenzyl thiourea derivatives and improved lipid compositions containing same 有权

公开(公告)号：US07053243B2

公开(公告)日：2006-05-30

申请号：US10633252

申请日：2003-08-01

申请人： Thomas P. Abbott , Alan Wohlman

发明人： Thomas P. Abbott , Alan Wohlman

IPC分类号： C07C335/12 , C07C335/06 , C07C335/02 , C07C335/10

CPC分类号： C11B5/0042 , A61K8/46 , A61K2800/522 , A61Q5/00 , A61Q17/00 , A61Q17/04 , A61Q19/00

摘要： 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.

8.

发明申请
Novel aryl urea analogs and use thereof as antibacterial agents 审中-公开
标题翻译：新型芳基脲类似物及其作为抗菌剂的用途

公开(公告)号：US20060030603A1

公开(公告)日：2006-02-09

申请号：US10913683

申请日：2004-08-05

申请人： Punit Seth , Dale Robinson , Elizabeth Jefferson , Eric Swayze

发明人： Punit Seth , Dale Robinson , Elizabeth Jefferson , Eric Swayze

IPC分类号： A61K31/44 , A61K31/17 , C07D213/54 , C07C335/12

CPC分类号： C07C275/34 , C07C275/30 , C07C335/16 , C07D207/34 , C07D213/38 , C07D213/61 , C07D307/56

摘要： Antibacterial compounds are described herein having either formula (I) or formula (II): wherein R1A, R1B, R1C, R1D, X, Z, Q, R2A, R2B, R2C and R2D are as defined herein. Compositions comprising compounds of formulas (I) and (II) are also provided.

摘要翻译： 本文描述了具有式（I）或式（II）的抗菌化合物：其中R 1A，R 1B，R 1C，R“ X，Z，Q，R 2A，R 2B，R 2C和R 2D， / SUB>如本文所定义。还提供了包含式（I）和（II）化合物的组合物。