- 专利标题: Liquid pharmaceutical composition
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申请号: US15313487申请日: 2015-05-15
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公开(公告)号: US10426833B2公开(公告)日: 2019-10-01
- 发明人: Gianluca Rinaldi , Silvia Fratarcangeli , Alessandra Del Rio
- 申请人: Fresenius Kabi Deutschland GmbH
- 申请人地址: DE Bad Homburg
- 专利权人: Fresenius Kabi Deutschland GmbH
- 当前专利权人: Fresenius Kabi Deutschland GmbH
- 当前专利权人地址: DE Bad Homburg
- 代理机构: Goodwin Procter LLP
- 优先权: EP14169755 20140523
- 国际申请: PCT/EP2015/060818 WO 20150515
- 国际公布: WO2015/177059 WO 20151126
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K9/00 ; C07K16/24 ; A61K47/12 ; A61K47/26
摘要:
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, a citrate buffering agent/system such as sodium citrate/citric acid, and a sugar stabilizer such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. prefilled syringes) to reduce unnecessary waste of the drug.
公开/授权文献
- US20170182162A1 LIQUID PHARMACEUTICAL COMPOSITION 公开/授权日:2017-06-29
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