Methods, apparatus, systems, and articles of manufacture to facilitate field-programmable gate array support during runtime execution of computer readable instructions are disclosed herein. An example apparatus includes a compiler to, prior to runtime, compile a block of code written as high level source code into a first hardware bitstream kernel and a second hardware bitstream kernel; a kernel selector to select the first hardware bitstream kernel based on an attribute to be dispatched during runtime; a dispatcher to dispatch the first hardware bitstream kernel to a field programmable gate array (FPGA) during runtime; and the kernel selector to, when an FPGA attribute does not satisfy a threshold during runtime, adjust the selection of the first hardware bitstream kernel to the second hardware bitstream kernel to be dispatched during runtime.