Systems, methods, and apparatus for line multiplexed serial interfaces are disclosed. A method performed by a receiving device includes detecting a first transition in a signal received from a receive line of a UART after the receive line has been idle or following transmission of a stop bit on the receive line, detecting a second transition in the signal, synchronizing a sampling clock to the second transition, where clock cycles of the sampling clock are double the duration between the first transition and the second transition, and using the sampling clock to capture a byte of data from the receive line. One clock cycle of the sampling clock may be consumed while receiving each bit of data.