Systems, methods, and apparatus for communication virtualized general-purpose input/output signals over a serial communication link A method performed at a transmitting device coupled to a communication link includes configuring general-purpose input/output (GPIO) state from a plurality of sources into a virtual general-purpose input/output word, identifying one or more destinations for the first GPIO word based on a mapping of the GPIO state to one or more devices coupled to a serial bus, and transmitting the first GPIO word to each destination.