Invention Grant
- Patent Title: Chiral resolution method of N-[4-(1-aminoethyl)-phenyl]-sulfonamide derivatives
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Application No.: US15325349Application Date: 2016-02-15
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Publication No.: US10479763B2Publication Date: 2019-11-19
- Inventor: Byoung Young Woo , Ki-Wha Lee , Kwang-Hyun Shin , Miyoung Park , Kyoungmi Jung , Joonho Choi , Gyeyoung Choi , Wonkyung Cho , Young-Ho Park
- Applicant: AMOREPACIFIC CORPORATION
- Applicant Address: KR Seoul
- Assignee: AMOREPACIFIC CORPORATION
- Current Assignee: AMOREPACIFIC CORPORATION
- Current Assignee Address: KR Seoul
- Agency: Cantor Colburn LLP
- Priority: KR10-2015-0024334 20150217; EP15174617 20150630
- International Application: PCT/KR2016/001474 WO 20160215
- International Announcement: WO2016/133317 WO 20160825
- Main IPC: C07C303/42
- IPC: C07C303/42 ; C07C303/36 ; C07C311/08 ; C07C303/44 ; C07D213/56 ; C07B57/00 ; C07C63/06
![Chiral resolution method of N-[4-(1-aminoethyl)-phenyl]-sulfonamide derivatives](/abs-image/US/2019/11/19/US10479763B2/abs.jpg.150x150.jpg)
Abstract:
The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.
Public/Granted literature
- US20170342027A1 CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES Public/Granted day:2017-11-30
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