公开(公告)号：US12059412B2

公开(公告)日：2024-08-13

申请号：US16976140

申请日：2019-03-21

Applicant: Amorepacific Corporation

Inventor： Joonho Choi ,  Wonkyung Cho ,  Jong Hwa Roh ,  Kwanghyun Shin ,  Byoung Young Woo ,  Min Soo Kim ,  Miyoung Park ,  Youngho Park ,  Eunsil Park ,  Jaehong Park ,  Kiwha Lee

IPC: A61K31/44 ,  A61K9/00 ,  A61K31/79 ,  A61K47/32

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61K47/32

Abstract: One aspect of the present disclosure relates to a pharmaceutical composition, containing (R)-N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first ingredient and containing a vinylpyrrolidone-based polymer as a second ingredient. The composition of one aspect of the present disclosure has a formulation characteristic in which the crystal formation of a compound represented by chemical formula 1 is delayed for a long time.

公开(公告)号：US11878008B2

公开(公告)日：2024-01-23

申请号：US16805381

申请日：2020-02-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Gyeyoung Choi ,  Hyunjin Nam ,  Miyoung Park ,  Kyoungmi Jung ,  Jihae Lee ,  Chang Soon Choi ,  Youngho Park ,  Jong Hwa Roh ,  Eunsil Park ,  Jaehong Park ,  Kwanghyun Shin ,  Byoung Young Woo ,  Kiwha Lee ,  Wonkyung Cho ,  Joonho Choi

IPC: A61P17/04 ,  A61K31/44 ,  A61K9/00

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61P17/04

Abstract: Disclosed is a method for preventing or treating atopic dermatitis using TRPV1 receptor antagonist. More specifically, it may be possible to prevent and/or treat the atopic dermatitis without any side effects such as an increase in body temperature, epidermal atrophy, and the like by percutaneously administrating a composition for external use on the skin containing the TRPV1 receptor antagonist.

公开(公告)号：US11957669B2

公开(公告)日：2024-04-16

申请号：US16638038

申请日：2018-08-10

Applicant: AMOREPACIFIC CORPORATION

Inventor： Joon Ho Choi ,  Won Kyung Cho ,  Kwang-Hyun Shin ,  Byoung Young Woo ,  Ki-Wha Lee ,  Min-Soo Kim ,  Jong Hwa Roh ,  Mi Young Park ,  Young-Ho Park ,  Eun Sil Park ,  Jae Hong Park

IPC: A61K31/44 ,  A61K9/00 ,  A61K47/38

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61K47/38

Abstract: One aspect of the present disclosure is a pharmaceutical composition which includes (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of one aspect of the present disclosure has a formulation characteristic in which crystal formation is delayed for a long time.

公开(公告)号：US11382900B2

公开(公告)日：2022-07-12

申请号：US16805202

申请日：2020-02-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Gyeyoung Choi ,  Hyunjin Nam ,  Miyoung Park ,  Kyoungmi Jung ,  Jihae Lee ,  Chang Soon Choi ,  Youngho Park ,  Jong Hwa Roh ,  Eunsil Park ,  Jaehong Park ,  Kwanghyun Shin ,  Byoung Young Woo ,  Kiwha Lee ,  Wonkyung Cho ,  Joonho Choi

IPC: A61K31/44 ,  A61K9/00 ,  A61K9/06

Abstract: Disclosed is a method for preventing or treating sleep disorders using TRPV1 receptor antagonist, (R)—N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide. The method of the present invention can effectively and safely prevent or treat sleep disorders accompanying pruritus caused by atopic dermatitis.

公开(公告)号：US10479763B2

公开(公告)日：2019-11-19

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Ki-Wha Lee ,  Kwang-Hyun Shin ,  Miyoung Park ,  Kyoungmi Jung ,  Joonho Choi ,  Gyeyoung Choi ,  Wonkyung Cho ,  Young-Ho Park

IPC: C07C303/42 ,  C07C303/36 ,  C07C311/08 ,  C07C303/44 ,  C07D213/56 ,  C07B57/00 ,  C07C63/06

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

公开(公告)号：US20150290099A1

公开(公告)日：2015-10-15

申请号：US14648687

申请日：2013-11-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Won Hee Jang ,  Yung Hyup Joo ,  Yang Hui Park ,  Chang Geun Yi ,  Young Suk Cho ,  Heung Soo Baek ,  Song Seok Shin ,  Young Ho Park

IPC: A61K8/42 ,  A61Q19/00

CPC classification number: A61K8/42 ,  A61K8/68 ,  A61K2800/40 ,  A61Q19/007 ,  C07C233/18 ,  C07C235/08 ,  C07C235/28

Abstract: The present invention provides: a novel pseudoceramide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. The present invention has a skin protecting effect in that the invention has a superior effect in skin moisturisation and is outstandingly stable and soluble, and thus the invention can protect the skin from external irritation without side effects, and can be used as an active substance in damaged skin recovery and prevention. Consequently, the invention can be used as a skin-moisturising dermatological external composition, cosmetic composition or pharmaceutical composition.

Abstract translation: 本发明提供：新颖的假花生酰胺化合物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂化物。 本发明具有皮肤保护作用，因为本发明在皮肤保湿中具有优异的效果，并且具有优异的稳定和可溶性，因此本发明可以保护皮肤免受外部刺激而没有副作用，并可用作活性物质 皮肤恢复和预防受损。 因此，本发明可以用作皮肤保湿皮肤病外用组合物，化妆品组合物或药物组合物。

公开(公告)号：US11998633B2

公开(公告)日：2024-06-04

申请号：US17289382

申请日：2019-10-16

Applicant: Amorepacific Corporation

Inventor： Wonkyung Cho ,  Kwanghyun Shin ,  Joonho Choi ,  Kiwha Lee ,  Jong Hwa Roh ,  Miyoung Park ,  Youngho Park ,  Eunsil Park ,  Jaehong Park ,  Byoung Young Woo ,  Min Soo Kim ,  Eun Sol Ha

IPC: A61K9/08 ,  A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/00

CPC classification number: A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

Abstract: One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.

公开(公告)号：US11992541B2

公开(公告)日：2024-05-28

申请号：US17512347

申请日：2021-10-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Yong Deog Hong ,  Joonyoung Hwang

IPC: A61K8/06 ,  A61K8/92 ,  A61K8/9789 ,  B82Y5/00

CPC classification number: A61K8/068 ,  A61K8/922 ,  A61K8/9789 ,  A61K2800/21 ,  A61K2800/413 ,  B82Y5/00

Abstract: The present disclosure relates to a nanoemulsion cosmetic composition including an oil phase and an aqueous phase, wherein the oil phase contains a ginseng nanopowder and an oil swollen by the ginseng nanopowder, the composition does not contain an additional surfactant, and the ginseng nanopowder is distributed uniformly in the composition. According to the present disclosure, there is provided a nanoemulsion cosmetic composition which contains a natural substance by containing a ginseng nanopowder and an oil swollen by the ginseng nanopowder in an oil phase and provides beneficial effect to skin.

公开(公告)号：US10858315B2

公开(公告)日：2020-12-08

申请号：US16337729

申请日：2017-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Ki-Wha Lee ,  Jihae Lee ,  Chang Soon Choi ,  Miyoung Park ,  Young-Ho Park ,  Sarva Jayaprakash ,  Sridhar Regati ,  Mamidi Srinivas ,  Krushnakant Patel ,  M. Ramamohan

IPC: C07C311/08 ,  B01D9/00 ,  C07C303/44 ,  B01L9/00

Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the recrystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

公开(公告)号：US10696611B2

公开(公告)日：2020-06-30

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Song Seok Shin ,  Byoung Young Woo ,  Heung Soo Baek ,  Yong Deog Hong ,  Hong-Ju Shin ,  Yeon Su Jeong ,  Jon Hwan Lee

IPC: C07C239/00 ,  C07D453/02 ,  C07D413/00 ,  A61K31/16 ,  C07C13/615 ,  C07C233/59 ,  A61K31/167 ,  A61K8/42 ,  C07C233/60 ,  A61K8/49 ,  A61Q7/00 ,  A61K31/166 ,  C07C233/63 ,  C07C231/02 ,  C07C233/58 ,  C07C265/12 ,  A61Q19/00 ,  C07D263/56 ,  C07C15/04 ,  C07C233/57 ,  A61K31/4184

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.