Invention Grant
- Patent Title: Compositions and methods for screening T cells with antigens for specific populations
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Application No.: US15170919Application Date: 2016-06-01
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Publication No.: US10481158B2Publication Date: 2019-11-19
- Inventor: James R. Heath , Songming Peng
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Goodwin Procter LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12Q1/68 ; C07H21/04 ; G01N33/569 ; C12Q1/6804 ; G01N15/14 ; G01N33/574 ; G01N33/68 ; G01N15/00
Abstract:
Compositions and methods for isolating patient-derived antigen-specific T cells include an antigen complex having a polynucleotide barcoded nanoparticle sorting agent complexed with a peptide-loaded streptavidin major histocompatability complex (MHC) tetramer, the barcoding technology allowing for high fidelity screening of a library of the antigen complexes to readily isolate and identify antigen-specific T cells.
Public/Granted literature
- US20170003288A1 COMPOSITIONS AND METHODS FOR SCREENING T CELLS WITH ANTIGENS FOR SPECIFIC POPULATIONS Public/Granted day:2017-01-05
Information query
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