Invention Grant
- Patent Title: Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
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Application No.: US16387937Application Date: 2019-04-18
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Publication No.: US10508077B2Publication Date: 2019-12-17
- Inventor: Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: FORMA Therapeutics, Inc.
- Current Assignee: FORMA Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent Michael A. Shinall; Nicholas J. Pace
- Main IPC: C07C259/06
- IPC: C07C259/06 ; C07D471/04 ; A61K31/5377 ; A61K31/4439 ; C07D417/04 ; A61K31/495 ; C07D241/08 ; A61K31/44 ; C07D213/56 ; A61K31/417 ; C07D233/68 ; A61K31/4184 ; C07D235/14 ; A61K31/397 ; A61K31/407 ; C07D487/10 ; A61K31/435 ; C07D471/10 ; A61K31/451 ; C07D295/155 ; A61K31/4035 ; C07D209/44 ; A61K31/277 ; A61K31/438 ; A61K31/185 ; C07D495/10 ; C07D221/20 ; C07D307/68 ; C07D213/65 ; C07D295/192 ; C07D211/58 ; C07D211/16 ; C07D513/10 ; C07D209/46 ; C07D209/42 ; C07D277/56 ; C07D209/08 ; C07D498/04 ; C07D207/267 ; C07D493/08 ; C07D207/10 ; C07D491/10 ; C07D487/08 ; C07D487/04 ; C07D261/18 ; C07D257/04 ; C07D249/18 ; C07D417/12 ; C07D241/12 ; C07D409/12 ; C07D409/04 ; C07D405/12 ; C07D239/22 ; C07D239/20 ; C07D235/30 ; C07D401/12 ; C07D401/04 ; C07D333/70 ; C07D233/38 ; C07D233/36 ; C07D231/18 ; C07D231/14 ; C07D317/68 ; C07D215/12 ; C07D213/81 ; C07D213/75 ; C07D401/14
Abstract:
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
Public/Granted literature
- US20190241506A1 ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS Public/Granted day:2019-08-08
Information query
