An electrical multi-connector feedthrough panel for sealing a penetration in a structure across a pressure differential, the panel including a frame having a first environmental interface surface and a second environmental interface surface configured to couple with the structure so that the first environmental interface surface and the second environmental interface surface span the penetration so as to at least in part seal the penetration, and a plurality of electrical connector insert shells monolithically formed with the frame, each of the plurality of electrical connector insert shells being configured to sealingly couple with at least one electrical connector, where the first environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a first pressurized environment, and the second environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a second pressurized environment.