- 专利标题： Amine solvate of sodium-glucose linked transporter inhibitor, and preparation method and application thereof
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申请号： US16096119申请日： 2017-03-27
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公开(公告)号： US10519183B2公开(公告)日： 2019-12-31
- 发明人: Lei Zhang , Yuan Wang
- 申请人： Youngene Therapeutics Co., Ltd.
- 申请人地址： CN Shanghai
- 专利权人： Youngene Therapeutics Co., Ltd.
- 当前专利权人： Youngene Therapeutics Co., Ltd.
- 当前专利权人地址： CN Shanghai
- 代理机构： Schwegman Lundberg & Woessner, P.A.
- 优先权： CN201610296693 20160504
- 国际申请： PCT/CN2017/078309 WO 20170327
- 国际公布： WO2017/190568 WO 20171109
- 主分类号： C07H15/00
- IPC分类号： C07H15/00 ; C07H15/04 ; C07H9/04 ; C07H7/04 ; C07H19/01 ; A61K31/7048 ; C07H1/00
摘要：
Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.
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