公开(公告)号：US10519183B2

公开(公告)日：2019-12-31

申请号：US16096119

申请日：2017-03-27

申请人： Youngene Therapeutics Co., Ltd.

发明人： Lei Zhang ,  Yuan Wang

IPC分类号： C07H15/00 ,  C07H15/04 ,  C07H9/04 ,  C07H7/04 ,  C07H19/01 ,  A61K31/7048 ,  C07H1/00

摘要： Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

公开(公告)号：US20190135848A1

公开(公告)日：2019-05-09

申请号：US16096119

申请日：2017-03-27

申请人： Youngene Therapeutics Co., Ltd.

发明人： Lei Zhang ,  Yuan Wang

IPC分类号： C07H19/01

摘要： Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.