The invention provides a mobile networking method and system for minimizing interference. The mobile networking method comprises the following steps: unmanned aerial vehicles establish connection and communication with ground base stations through a wireless relay method; connection and communication between the unmanned aerial vehicles are established through a wireless self-networking method; multiple unmanned aerial vehicles cooperate to form a cellular network to provide wireless network services for users; the unmanned aerial vehicles receive a received signal strength indicator fed back by an user equipment and measure an angle of arrival of a signal beam from the user equipment; the main lobe of a signal is made to aim at the direction of arrival of service users through a mobile interference alignment method and a beam forming method thus enabling the optimal hovering position of the unmanned aerial vehicle to be obtained.