- 专利标题： Polyplex of double-stranded RNA and polymeric conjugate
-
申请号： US16297133申请日： 2019-03-08
-
公开(公告)号： US10543232B2公开(公告)日： 2020-01-28
- 发明人: Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
- 申请人： TARGIMMUNE THERAPEUTICS AG
- 申请人地址： CH Basel
- 专利权人： TargImmune Therapeutics AG
- 当前专利权人： TargImmune Therapeutics AG
- 当前专利权人地址： CH Basel
- 代理机构： Knobbe, Martens, Olson & Bear, LLP
- 主分类号： A61K47/34
- IPC分类号： A61K47/34 ; A61K35/14 ; A61K45/06 ; C12N15/117 ; A61K47/60 ; A61K47/59 ; A61K35/17
摘要：
A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).
公开/授权文献
- US20190192563A1 POLYPLEX OF DOUBLE-STRANDED RNA AND POLYMERIC CONJUGATE 公开/授权日：2019-06-27
信息查询
IPC分类:
