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公开(公告)号：US20220175814A1
公开(公告)日：2022-06-09
申请号：US17594054
申请日：2020-04-03
发明人： Derrick BROKA , David COLECCHIA , Lucia D'AMICO , Eric KITAS , Alexander LEVITZKI , Esteban POMBO-VILLAR , Alexei SHIR , Maya ZIGLER , Davor BAJIC , Anita JARZEBINSKA
摘要： The present invention relates to a kit-of-parts comprising and a composition comprising a polyplex comprising a double stranded RNA (dsRNA) and a polymeric conjugate comprising a polyethyleneimine (PEI), one or more polyethylene glycol (PEG) moieties and one or more targeting moieties, and wherein each of said one or more targeting moieties is capable of binding to a cancer antigen; and at least one antibody, wherein said at least one antibody is capable of modulating an immune checkpoint protein. Further the invention relates to this composition or kit-of-parts for use in the treatment of cancer.
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公开(公告)号：US20230372384A1
公开(公告)日：2023-11-23
申请号：US18247961
申请日：2021-10-07
发明人： Esteban POMBO-VILLAR , Eric KITAS , Maya ZIGLER , Davor BAJIC , Babette SCHADE , Derrick BROKA
IPC分类号： A61K31/713 , C07K16/28 , A61P35/00
CPC分类号： A61K31/713 , C07K16/2818 , A61P35/00
摘要： The present invention relates to a kit-of-parts comprising and a composition comprising a polyplex comprising a double stranded RNA (dsRNA) and a polymeric conjugate comprising a polyethyleneimine (PEI), one or more polyethylene glycol (PEG) moieties and one or more targeting moieties, and wherein each of said one or more targeting moieties is capable of 5 binding to PSMA; and at least one least one immune checkpoint modulator, wherein said at least one least one immune checkpoint modulator is capable of modulating an immune checkpoint protein. Further the invention relates to this composition or kit-of-parts for use in the treatment of cancer.
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公开(公告)号：US11230580B2
公开(公告)日：2022-01-25
申请号：US15915770
申请日：2018-03-08
发明人： Alexander Levitzki , Yael Langut , Nufar Edinger
摘要： Described herein are recombinant chimeric proteins comprising a double stranded RNA (dsRNA) binding domain and a cancer-cell targeting domain for targeting of dsRNA to cancer cells. Methods of use of the described chimeric proteins are also provided herein.
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公开(公告)号：US10278991B2
公开(公告)日：2019-05-07
申请号：US15310735
申请日：2015-05-14
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
摘要： A polyplex of a double stranded RNA and a polymeric conjugate is provided, wherein the polymeric conjugate consists of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties, each PEG moiety being conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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公开(公告)号：US11679160B2
公开(公告)日：2023-06-20
申请号：US16650980
申请日：2018-09-27
发明人： Esteban Pombo-Villar , Alexander Levitzki , Yael Langut , Maya Zigler , Alexei Shir , Eric Kitas
摘要： The present invention relates to a polyplex for use in the treatment of castration resistant prostate cancer (CRPC) comprising a double stranded RNA (dsRNA) and a polymeric conjugate, wherein said polymeric conjugate consists of a linear polyethyleneimine (LPEl), one or more polyethylene glycol (PEG) moieties, one or more linkers and one or more targeting moieties, wherein said LPEl is covalently bound to one or more PEG moieties and each of said one or more PEG moieties is conjugated via one of the one or more linkers to one of the one or more targeting moieties, wherein each of said one or more targeting moieties is capable of binding to a cancer antigen, and wherein said cancer antigen is prostate surface membrane antigen (PSMA). Further, the invention relates to a pharmaceutical composition for use in the treatment of CRPC.
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公开(公告)号：US10543232B2
公开(公告)日：2020-01-28
申请号：US16297133
申请日：2019-03-08
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
摘要： A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).
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公开(公告)号：US11912747B2
公开(公告)日：2024-02-27
申请号：US16329577
申请日：2016-12-15
发明人： Alexander Levitzki , Yael Langut
CPC分类号： C07K14/4748 , A61K47/6851 , A61P35/00 , C07K16/3069 , C12N15/117 , C12N15/62 , A61K38/00 , A61K47/68 , A61K47/6869 , C07K2317/622 , C07K2317/77 , C07K2319/60 , C07K2319/85 , C12N2310/17 , C12N2320/32
摘要： Described herein are recombinant chimeric proteins comprising a double stranded RNA (dsRNA) binding domain and a cancer-cell targeting domain for targeting of dsRNA to cancer cells. Methods of use of the described chimeric proteins are also provided herein.
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公开(公告)号：US20240033364A1
公开(公告)日：2024-02-01
申请号：US18316828
申请日：2023-05-12
发明人： Esteban POMBO-VILLAR , Alexander LEVITZKI , Yael LANGUT , Maya ZIGLER , Alexei SHIR , Eric KITAS
摘要： The present invention relates to a polyplex for use in the treatment of castration resistant prostate cancer (CRPC) comprising a double stranded RNA (dsRNA) and a polymeric conjugate, wherein said polymeric conjugate consists of a linear polyethyleneimine (LPEI), one or more polyethylene glycol (PEG) moieties, one or more linkers and one or more targeting moieties, wherein said LPEI is covalently bound to one or more PEG moieties and each of said one or more PEG moieties is conjugated via one of the one or more linkers to one of the one or more targeting moieties, wherein each of said one or more targeting moieties is capable of binding to a cancer antigen, and wherein said cancer antigen is prostate surface membrane antigen (PSMA). Further, the invention relates to a pharmaceutical composition for use in the treatment of CRPC.
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公开(公告)号：US20220339189A1
公开(公告)日：2022-10-27
申请号：US17653221
申请日：2022-03-02
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
IPC分类号： A61K35/14 , A61K45/06 , C12N15/117 , A61K47/60 , A61K47/59
摘要： A method of treating cancer may include administering a polyplex of a double stranded RNA and a polymeric conjugate. The polymeric conjugate may consist of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety may be conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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公开(公告)号：US20220213158A1
公开(公告)日：2022-07-07
申请号：US17582160
申请日：2022-01-24
发明人： Alexander LEVITZKI , Yael Langut , Nufar Edinger
摘要： Described herein are recombinant chimeric proteins comprising a double stranded RNA (dsRNA) binding domain and a cancer-cell targeting domain for targeting of dsRNA to cancer cells. Methods of use of the described chimeric proteins are also provided herein.
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